최경운
Ahrong Kim
Eun Young Park
Kyungbin Kim
Jeong Hee Lee
Dong Hoon Shin
Jee Yeon Kim
Do Youn Park
Chang Hun Lee
Mee Young Sol
Kyung Un Choi
Jeung Il Kim
In Sook Lee
2016-04-19T11:18:44Z
2016-04-19T11:18:44Z
2014
1477-7819
2015-OAK_2014_SCI_최경운_1
http://repository.pnuh.or.kr/handle/2015.OAK/415
BACKGROUND:
Soft tissue sarcomas (STS) are rare. We evaluated the WT1 protein expression level in various types of STS and elucidated the value of WT1 as a prognostic factor and a possible therapeutic target.
METHODS:
Immunohistochemical staining for WT1 was performed in 87 cases of STS using formalin-fixed, paraffin-embedded blocks. The correlation between WT1 expression and clinicopathological factors was analyzed. Survival analysis was conducted in 67 patients. We assessed the validity of WT1 immunohistochemistry as an index of WT1 protein expression using Western blot analysis.
RESULTS:
WT1 expression was noted in 47 cases (54.0%). Most rhabdomyosarcomas and malignant peripheral nerve sheath tumors showed WT1 expression (91.7% and 71.4%, respectively
P?=?0.005). WT1 expression was related to higher FNCLCC histologic grade and AJCC tumor stage. In the group with high grade STS, strong WT1 expression was correlated with better survival (P?=?0.025). The immunohistochemical results were correlated quantitatively with the staining score and the concentration of the Western blot band.
CONCLUSIONS:
This study demonstrates that various types of STS show positive immunostaining for WT1 and that WT1 expression has a prognostic significance. So STS should be considered candidates for WT1 peptide--based immunotherapy.
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Previous issue date: 2014
pdf
Prognostic significance of WT1 expression in soft tissue sarcoma
Thesis
병리과
Choi, Kyung Un
12
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