Soluble alpha-Klotho as a Novel Biomarker in the Early Stage of Nephropathy in Patients with Type 2 Diabetes
- Soluble alpha-Klotho as a Novel Biomarker in the Early Stage of Nephropathy in Patients with Type 2 Diabetes
- Eun Young Lee; Sang Soo Kim; Ji-Sung Lee; In Joo Kim; Sang Heon Song; Seung-Kuy Cha; Kyu-Sang Park; Jeong Suk Kang; Choon Hee Chung
- Kim, Sang Soo
Although α-klotho is known as an anti-aging, antioxidant, and cardio-renal protective protein, the clinical implications of soluble α-klotho levels in patients with diabetes have not been evaluated. Therefore, this study evaluated whether plasma and urinary α-klotho levels are associated with albuminuria in kidney disease in diabetes.
RESEARCH DESIGN AND METHODS:
A total of 147 patients with type 2 diabetes and 25 healthy control subjects were enrolled. The plasma and urine concentrations of α-klotho were analyzed by enzyme-linked immunosorbent assay.
Plasma α-klotho (572.4 pg/mL [95% CI, 541.9-604.6 pg/mL] vs. 476.9 pg/mL [95% CI, 416.9-545.5 pg/mL]) and urinary α-klotho levels (59.8 pg/mg creatinine [95% CI, 43.6-82.0 pg/mg creatinine] vs. 21.0 pg/mg creatinine [95% CI, 9.7-45.6 pg/mg creatinine]) were significantly higher in diabetic patients than non-diabetic controls. Among diabetic patients, plasma α-klotho concentration was inversely associated with albuminuria stages (normoalbuminuria, 612.6 pg/mL [95% CI, 568.9-659.6 pg/mL], microalbuminuria, 551.8 pg/mL [95% CI, 500.5-608.3 pg/mL], and macroalbuminuria, 505.7 pg/mL [95% CI, 439.7-581.7 pg/mL] (p for trend ？= 0.0081), while urinary α-klotho levels were remained constantly high with increasing urinary albumin excretion.
Soluble α-klotho levels in plasma and urine may be novel and useful early markers of diabetic renal injury
- Appears in Collections:
- Kim, Sang Soo(김상수)
- Files in This Item:
- 2014_SCI_김상수_1.pdf(244.18 kB)Download
- RIS (EndNote)
- XLS (Excel)